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KMID : 0870420120160020065
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2012 Volume.16 No. 2 p.65 ~ p.69
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Peripheral eosinophilia - is it a predictable factor associated with eosinophilic cholecystitis?
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Yeom Seung-Seop
Kim Ho-Hyun
Kim Jung-Chul
Hur Young-Hoe
Koh Yang-Seok
Cho Chol-Kyoon
Kim Hyun-Jong
Sin Sang-Su
Kim Hyung-Seok
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Abstract
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Background/Aims: The purpose of this study was to evaluate the role of peripheral eosinophilia as a predictable factor associated with Eosinophilic cholecystitis (EC) compared with other forms of cholecystitis in patients who underwent a cholecystectomy.
Methods: Between January 2001 and May 2011, the histopathologic features of 3,539 cholecystectomy specimens were reviewed retrospectively. EC was diagnosed in 30 specimens (0.84%). Data from 30 consecutive patients with EC (eosinophilic cholecystitis group [E-group]) were compared with a retrospective control group of 60 patients (other cholecystitis group [O-group]) during the same period. The two groups were matched for age, gender, and the presence of cholelithiasis.
Results: The median absolute eosinophil count 1 day post-operatively was 144 cells/mm3 (range: 9-801 cells/mm3) in the E-group and 93 cells/mm3 (range: 0-490 cells/mm3) in the O-group (p=0.036). Pre-operative peripheral eosinophilia was more common in the E-group than the O-group (20% vs. 3.3%, p=0.015). Multivariate analysis revealed that pre-operative peripheral eosinophilia was an independent significant predictable factor associated with EC (odds ratio=7.250, 1.365 ＜95% confidence interval＜38.494, p=0.020).
Conclusions: In the present study, pre-operative peripheral eosinophilia was shown to be an independent predictable factor associated with EC. Further researches seem to be necessary to confirm this finding.
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KEYWORD
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Eosinophilic cholecystitis, Eosinophilia, Predictable factor, Cholecystectomy
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